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Ameloblastic Carcinoma: A Clinical Case Report

Case Report

Article Title: Ameloblastic Carcinoma: A Clinical Case Report

Author: Judith Avendaño González, Guillermo García Garduño, Humberto Hernández Ojeda, Maria de Lourdes Castellanos Villalobos, Ernesto Levet Gorozpe and Rosa Maria Torres Hernández*

Published Date: January 07, 2026

DOI: 10.26717/BJSTR.2026.64.010031

Abstract:

Ameloblastic carcinoma is a rare pathological entity, accounting for approximately 2% of head and neck tumors. It behaves as a malignant neoplasm with locally invasive destructive capacity, including neural involvement, lymphatic dissemination, and slow-growing distant metastases, leading to bone resorption and dental mobility [1,2]. Clinical Case: We report the case of a 45-year-old male patient who presented with left mandibular swelling since the age of 12. Facial computed tomography revealed a lobulated hypodense lesion measuring 5 × 6 cm in the left mandible, associated with bone lysis. Excisional surgical removal under general anesthesia was performed, including mandibular hemimandibulectomy and placement of a reconstruction plate. Histopathological examination revealed a malignant odontogenic neoplasm composed of islands, cords, and sheets of ameloblastomatous epithelium. Conclusion: The transformation from ameloblastoma to ameloblastic carcinoma remains controversial. The most relevant feature appears to be prolonged evolution over time. In this patient, the lesion began as a small mandibular tumor at 12 years of age, remained untreated, and progressed to facial deformity, intraoral ulcerations, dental mobility, and pain.

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