Article Title: The Janus head of small Molecules on Drug Targets
Author: Johann Leban*
Published Date: December 19, 2022
‘Drug promiscuity’ refers to a drug that can act on more than one molecular target, by binding specifically to separate proteins exhibiting similar or different pharmacological effects. Three examples of such compounds from my own past work are presented here. The focus is on the interesting phenomena of compound promiscuity and not on the vast field of DHODH biology, which is out of the scope of this short review.