Article Title: Autism and Renal Sulfate Transport
Author: Richard J Williams
Published Date: June 20, 2023
Sulfate is an important nutrient and enzyme cofactor. Blood sulfate is depressed for individuals with autism, partly due to poor resorption in the kidney. We model the kidney nephron using simple mathematics and examine flowrates, concentrations and resorption along the length of the proximal tubule. Three math experiments are performed using our kidney model. Assuming constant resorption, NaS1 transport protein density is examined. Blood levels of sulfite and thiosulfate inhibitors are increased to show their influence on neurotypicals. Then blood sulfate is varied to show how inhibitor levels may be decreased, potentially resulting in symptom relief and improvement of overall health for those on the spectrum. Expression of the NaS1 transport protein is linked to vitamin D and estrogen chemistry, suggesting feedback mechanisms for sulfate homeostasis. Finally, sulfate supplementation and sulfite avoidance are discussed as potential strategies for both the prevention and treatment of autism.