We aim to show a little but precise picture of the primary visual area, V1, in the human brain showing as it is a gateway of our brain to the external world. 28 Calabrian male patients (age range 51–84 years; mean age, 73.2 ± 1.57 years) showing a mean disease duration of 4.4 ± 0.91 years (range 1.0–23 years) were analyzed. 28 controls matched for sex and age were enrolled. An ophthalmologist examined all patients and controls in order to rule out diabetic retinopathy, cataracts, senile maculopathy, or ocular fundus’ anomalies. The clinical evidence makes such a plausible suggestion because the integrity of both areas V1 and V4 is critical to be consciously aware of having seen the colors. In these patients miss the intact return pathways from V4 to V1. Patients showing the color vision deficiency both on red/green, and/or on blue axis, can have no a great compromise of the V1 primary visual area. But, very likely both great or small compromise of the visual areas is related only to V4 color vision area. Within this group, the return pathways from V4 back to V1 showed to be critical for the conscious awareness of the color attributes of vision. The operational connections between the two areas are not very compromised, and it have restored after the surgical ventricular-peritoneal shunt. This interest is within a larger Research Project approved by Calabrian Ethic Committee.