Electronic cigarettes (E-cigarettes) entered the U.S. marketplace around 2006, and by 2014, they have become the most widely used tobacco product among U.S. youth. Between 2011 and 2015, E-cigarettes use among middle and high school students has increased 900%. In 2018, more than 3.8 million U.S. youth reported use of E-cigarettes. E-cigarettes present a health hazard to both users and nonusers, due to exposure to nicotine, other harmful substance, carcinogens and metal particles detected in the solution and aerosols of E-cigarettes. The risk related to this increase of E-cigarettes use among American youth necessitates regulatory efforts, legislative intervention, and proactive counter-promotion efforts to safeguard their well-beings. In addition, more research is needed to determine the public health effects of E-cigarettes among youth.