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Identification of Human Sialidase Inhibitors Using Three-Stage Virtual Screening of Natural Compounds

Human sialidases (neuraminidases) play a key role in the regulation of cellular processes, and their enzymatic activity is associated with inflammation, atherosclerosis, cancer, viral infections, lysosomal disorders. In this regard, a three-stage search for natural compounds that are potential inhibitors of human sialidase was conducted. At the first stage, the PubChem database was used, which helped to identify inhibitory activity in 36 compounds, 20 of which were flavonoids. At the second stag...

Environmental DNA and the Distributed Evolutionary Continuum: From Prebiotic Chemistry to Hybrid Biological Systems

The emergence and evolution of life are a continuum of processes governed by thermodynamics, which allows the continuous formation of increasingly complex systems able to store information and utilize energy. The current paradigm of evolution involves vertical inheritance, where organisms inherit genetic information from their progenitors and pass this genetic heritage to their descendants through reproduction. However, a growing body of evidence supports an alternative view of evolution as a di...

Efficient Impact Transfer on Bio Tissues in Wet Contact by the Water Clarified in Tube Condition

The natural water cycle is the largest transportation system and the major climate cooling element together with photosynthesis and wind powered by the sun. Water is a pure substance that picks and carries a huge load during its natural cycle on the earth, in the bio systems, in washing and cleaning, in medical care as well as in agriculture, power generation and industrial processes. It gets rid of the load by evaporation powered by the sun and wind, and leaves the civilization waste in the wat...

Alinasser’s Technique (Phrenoesophageal Ligament Reconstruction with Mesh) for Hiatal Hernia Repair: A Novel Approach

Hiatal hernia (HH) occurs when a portion of the stomach protrudes into the mediastinum through a weakened esophageal hiatus. Standard laparoscopic treatment involving reduction of the herniated stomach, cruroplasty, and fundoplication provides symptom relief but carries a high recurrence rate of 12–42%, even with mesh reinforcement. The phrenoesophageal ligament (PEL) plays a key role in maintaining the anatomical relationship between the esophagus and diaphragm, allowing independent motion du...