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A Cryptogenic Stroke Associated with Non-Infectious Endocarditis and Pai Mutation- Case Report

Case Report

Article Title: A Cryptogenic Stroke Associated with Non-Infectious Endocarditis and Pai Mutation- Case Report

Author: Maria Cholakova*, Nikolay Mihnev and Ivan Staikov

Published Date: December 04, 2024

DOI: 10.26717/BJSTR.2024.59.009277

Abstract:

Ischemic stroke is the most common neurological complication of endocarditis. Approximately 20% of patients with infective endocarditis (IE) present with stroke and in more than a third of them with nonbacterial thrombotic endocarditis (NBTE). Stroke is often one of the first symptoms of endocarditis. Population-based studies on cryptogenic stroke as defined by TOAST is 25% [1]. Not only the acquired risk factors are significant in vascular incidents, but also the genetic. The predisposition to thrombosis may be a result of genetic factors, acquired changes in the clotting mechanism or interaction between them. Impaired fibrinolytic function secondary to elevated plasminogen activator inhibitor-1 (PAI-1) levels has been implicated in ischemic stroke. We present a clinical case of a 33 year old female with several ischemic strokes with unknown cause.

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