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Natural Polyprenols Effects on the Immune System: A Mini Review and Own Results

Research Article

Article Title: Natural Polyprenols Effects on the Immune System: A Mini Review and Own Results

Author: Rubens J, Marakhouski Y Kh*, Roshchin V, Bartkevics V, Rubens A and Zajakina A

Published Date: September 18, 2024

DOI: 10.26717/BJSTR.2024.58.009192

Abstract:

Natural polyprenols have been studied for many years and a large number of articles have been published. However, a significant number of these publications are not indexed in official publication databases, i.e. they are classified as gray publications. Thus, over the past 5 years, only 16% of all articles on natural polyprenols have been published in peer-reviewed journals. Moreover, polyprenols themselves have complex classification characteristics that do not allow for a clear definition. It should also be noted that polyprenols are special lipids that are insoluble in water and have a low absorption threshold in their native form. To overcome this barrier, various chemical modifications of polyprenols are used, but the most physiologically complete form is the form based on fat particles in water that are close to natural micelles, which are the main ones in the physiology of lipid absorption in humans. A series of studies on the effect of natural polyprenols on immunity are characterized by fairly generalized assessments of the type of immunomodulation, immune activation with fairly vague assessments of the immune competent cells themselves and the degree of their participation in the effects of polyprenols. This primarily applies to macrophages as one of the key regulatory cells of immune reactions. The presented own research results show very promising developments in the nanoemulsion of polyprenols and their possible use for polarization of M2 macrophages, i.e. with an anti-inflammatory phenotype.

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