Oral mucosal pathologies have varied presentations, and their innocuous appearance can occasionally misguide even the specialist. Various oral diseases can be detected by sampling the mucosa. The biopsy is a process of removing an altered viable tissue from a living being to determine the nature of pathology by microscopic evaluation. This approach allows for confirmation of the histopathologic features of suspicious pathologies, their grade and stage, and an appropriate treatment plan. The biopsy is a primary diagnostic test for a range of oral lesions. It is required for those oral mucosal surfaces which demonstrate significant and tenacious changes in the colour or appearance. Although an array of biopsy techniques and tools exist, the utmost intention is to pick up a representative tissue that will aid in preparing an explicit histopathology report. We present a case of a suture thread incisional biopsy (IB) technique performed on a 32-year-old patient with an oral white lesion that resulted in a successful sample for histopathology. The sample taken provided flawless sections with precise histopathological features. This report illustrates a modified IB sampling technique and its utility. The suture thread IB technique was found to have many advantages over conventional IB techniques. However, the procedure needs highly skilled clinicians to perform it. Future investigations could elaborate on the merits and demerits of this technique.