Article Title: Finite Element Stimulation Analysis on Osteogenic Capacity of the Gelatin-Hybridized Calcium Phosphate Cement
Author: Tadaaki Morotomi*, Tomomi Iuchi, Tomokazu Fukuda, Kohei Ichinohashi, Hitoshi Nishiwaki, Koji Niwa and Noritaka Isogai
Published Date: March 14, 2018
When a bone defect is caused due to craniotomy, skull reconstruction is performed with titanium plates or hydroxyapatite in order to protect the brain and achieve an esthetically favorable outcome .These non-biodegradable osteo-inducing materials remain in the body and are never incorporated into the auto logos bone. Skull reconstruction using these materials often evokes postoperative complication such as protrusion, osteomyelitis, and instability. The use of biodegradable osteo-inducing biomaterial that can be spontaneously changed to the antilogous bone would be ideal for skull reconstruction; however, such biomaterial has not been developed yet. We previously developed an inject able, biodegradable osteo-inducing biomaterial (gelatin-hybridized calcium phosphate cement, gelatin-hybridized CPC, Gunze Ltd., Kyoto, Japan), and demonstrated its estrogenic capacity using a rat model with a full-thickness skull defect. In the present study, we performed a histological analysis to investigate the influences of the degree of cross-linking and volume of gelatin contained within gelatin - hybridized CPC on the osteogenic capacity. Furthermore, we performed finite element simulation analysis to examine the bone strength of the regenerated bone.