info@biomedres.us   +1 (502) 904-2126   One Westbrook Corporate Center, Suite 300, Westchester, IL 60154, USA   Site Map Crossmark Policy
ISSN: 2574 -1241

Impact Factor : 0.548

Menu

e-Prints

Bladder Cancers

Research Article

Article Title: Bladder Cancers

Author: Guy Lesec*, Seth P Lerner, David J Mc Conkey, Katherine A Hoadley, Keith S Chan, William Y Kim, François Radvanyi, Mattias Hoglund and Francisco X Real

Published Date: June 18, 2024

DOI: 10.26717/BJSTR.2024.57.008946

Abstract:

This long, somewhat tedious review would like to retrace the progress made in recent years by genetic progress and those made as a result in the understanding of tumor pathology. This path has led to a better definition of the subtypes of bladder carcinomas. Since the 2000s, methods for identifying genetic abnormalities in tumors have developed considerably qualitatively and quantitatively. Thanks to computers and high-throughput sequencing techniques, we can know, in a few hours or a few days, information that previously required weeks or months of investigation. The aim of this review is not only to list the genes involved in bladder tumours as it would be difficult to be exhaustive. The objective is to establish that it is possible, through reasoning on the transcriptome and the proteome, to give phenotypic expression a value established on its direct relationship with certain genetic abnormalities. A better knowledge of all these elements should allow pathologists to better coordinate with molecular biologists. The prior establishment of a tumor phenotype should make it possible to focus genetic investigations on smaller panels. After the description of FGFR3 mutations in 1999 and since the description of the genetic abnormalities that contributed to the establishment of the Madrid consensus in 2015 and the elements known today, we are witnessing a better understanding and a progressive simplification of the links with the phenotype. A new formulation emerges, next-generation immunohistochemistry, which draws a parallel with next-generation genetic sequencing. In this approach to genome, proteome, transcriptome relationships, it is the team from the Swedish University of LUND that has contributed the most to illuminating the classification of bladder tumors, with diagnostic, prognostic and predictive implications. The main articles analyzed in this review came from this working group.

Featured Reprints

view all