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Characteristic Appearances of Nodular Fasciitis on High-Resolution Ultrasonography: With Vasculature Status from A Lesion-Located Perspective

Review Article

Article Title: Characteristic Appearances of Nodular Fasciitis on High-Resolution Ultrasonography: With Vasculature Status from A Lesion-Located Perspective

Author: Kazumi Fujioka*

Published Date: August 20, 2019

DOI: https://dx.doi.org/10.26717/BJSTR.2019.20.003490

Abstract:

As nodular fasciitis (NF) is benign and self-limited, the clinical, ultrasonographic and pathological appearances have been described as mimicking sarcoma. NF has been cytogenetically considered as a novel model of transient neoplasia induced by MYH9-USP6 (myosin heary chain 9-ubiquitin -specific peptidase 6) gene fusion. It has been reported that the strong overexpression of USP6 under MYH9 promoter appears to drive tumorigenesis. The similar cytogenetic nature has been also demonstrated in both subcutaneous NF and intradermal type. The author previously described that the presentations of clinical, ultrasonographic and pathological features of NF are attributed to the cytogenetic nature, having the high proliferative growth and involutional nature. The author has also reported the characteristic power Doppler Ultrasonography (US) imaging of NF from a dermatological perspective and suggested that blood low signal is more detectable in intradermal NF than that in subcutaneous type. In this article, the current knowledge of the characteristic vasculature status in NF was reviewed from a lesion located perspective. The author will suggest that intradermal NF and subcutaneous NF, especially in a superficial location, close to or in contact with the dermis may show blood flow signal on color and power Doppler US.