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Article Title: PD-1/PD-L1 Checkpoint in Breast Implant-Associated Anaplastic Large Cell Lymphoma: A Case Report
Author: Antonella Bianchi*, Simona Ferrari, Gabriella Gullotta, Antonella Grasso, Ombretta Annibali
Published Date: March 16, 2018
Breast implant-associated anaplastic large cell lymphoma (BI-ALCL) is a rare form of malignancy that arises around mammary implants in patients undergoing prosthetic surgery. It has been included as a provisional entity in the revised WHO classification of lymphoid malignancy. The PD-1/PD-L1 axis is one of the major mechanisms of immune escaping exerted by several cancer types in which up-regulation of PD-L1 is observed. We report the presence of PD-1/PD-L1 checkpoint in a case of BI-ALCL of a 67 year old woman, whom previously had undergone mastectomy and reconstruction for breast carcinoma.