Assessment of Toxicity Issues of Bis-Coumarine Derivates and their Lanthanoid Complexes by Statistical Data Analysis

V Kircheva¹, D Josifov², M Milanova*¹, I Pancheva¹, J Zaharieva¹, M Nedyalkova¹, S Konstantinov², V Simeonov¹ and I Manolov³

Received: September 24, 2018;   Published: October 09, 2018

DOI: 10.26717/BJSTR.2018.09.001843

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Abstract

Complexes of some lanthanoids with several biscoumarin compounds such as 3,3’- benzylidenebis(4-hydroxy-2H-chromen-2-one), 3,3’-[(2-methoxyphenyl) methylene)]bis(4-hydroxy-2H-chromen-2-оne), 3’-[(4-methoxyphenyl)methylene)]bis(4-hydroxy-2H-chromen-2-оne) and 3,3’-[(4-chlorophenyl)methylene)]bis(4-hydroxy-2H-chromen-2-оne) were synthesized. The assessment of toxicity both ligands and the complexes formed was made through testing their antibacterial properties and cytotoxicity as two independent activities were studied. Three Gram-positive microorganisms were used, B. Mycoides, B. Subtilis and S. Lutea, applying the double layer agar hole diffusion method. The tested compounds were active against Gram-positive bacteria, but no activity was measured against Gram-negative bacteria. Cytotoxicity evaluation was made against cell lines such as K-562, BV-173, and SKW-3. The cluster analysis as a technique of the statistical data analysis was applied to the results obtained.

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