*Corresponding author:Sherin DR, Post Doctoral Fellow, Centre for Computational Modeling and Data Engineering, Indian Institute of Information Technology and Management-Kerala, Thiruvananthapuram, Kerala, india-695581, Trivandrum, Kerala-695581, India
Received: November 03, 2017; Published: November 15, 2017
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Breast cancer is one of the major causes of mortality in women. The estrogen receptor becomes positive in such patients. Many of the currently available anti breast cancer drugs produces severe side effects. It demands natural products with low toxicity to fight against estrogen receptor. In this point, we tried to establish antiestrogen potential of some natural flavonoids from the bark of Saraca asoca. The vitality of these drugs is well described in terms of pharmacokinetic parameters and molecular orbital analysis. In the light of molecular simulation studies we reports a set of lead compounds having natural origin in the treatment of breast cancer.
Keywords: Breast cancer; Estrogen receptor; Flavanoids; Catechins; Saraca asoca