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ISSN: 2574 -1241
ISSN: 2574 -1241
Received: December 17, 2018; Published: January 02, 2019
DOI: 10.26717/BJSTR.2018.12.002509
Vascular Extracellular Matrix (ECM) is a dynamic structure, which regulates blood vessel morphogenesis, provides organizational stability, and modulates various aspects of cell behavior [1]. Hyaluronan (HA) represents one of the most abundant macromolecules of the vascular wall. One of its main functions is to maintain blood vessel integrity [2]. Thus, any alteration in the metabolism of HA can predispose to the development and progression of atherosclerotic vascular diseases including diabetic macroangiopathy [3,4].
Abbreviations : CD44: Cluster Determinant 44; ECM: Extracellular Matrix; GlcNac: N-Acetylglucosamine; GlcUA: D-Glucuronic Acid; HA: Hyaluronan; HAS1-3; Hyaluronan Synthases 1-3; HMW: High Molecular Weight; HYALs; Hyaluronidases; IL-1β: Interleukin-1β; LMW: Low Molecular Weight; 4-MU: 4-Methylumbelliferone; ROS: Reactive Oxygen Species; TLRs: Toll Like Receptors; V(SMC) Vascular (Smooth Muscle Cell)
Introduction| Targeting HA in Atherosclerotic Vascular Diseases| Conclusion| References|
International Association of Landscape Archaeology, Czech Glass Society, Czech Republic
Department of Chemistry, Semenov Institute of Chemical Physics, USSR Academy of Sciences, Moscow, Russia
Pharmaco-kinetics, dynamics and Drug Metabolism, Touro College of Pharmacy, USA
Professor of Nuclear Medicine, Faculty of Medicine and Surgery, University of Milan, Milan, Italy
Associate Professor at Department of Breast and Thyorid Surgey, Chongqing General Hospital, China
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