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Serum Albumin Conformational Disturbances in Melancholic Depression can be Revealed Using Time Resolved Tryptophan Fluorescence

Volume 12 - Issue 1

Uzbekov M*1, Syrejshchikova T2, Smolina N1, Syromyatnikova E2, Brilliantova V1 and Dobretsov G3

  • Author Information Open or Close
    • 1Head of the Laboratory of Brain Pathology, Russia
    • 2Senior Researcher, Laboratory of High Energy, Russia
    • 3Leading researcher, laboratory of Biophysics in Medicine, Russia
    • *Corresponding author: Uzbekov MG, Head of the Laboratory of Brain Pathology, Moscow, Russia

Received: December 10, 2018;   Published: December 13, 2018

DOI: 10.26717/BJSTR.2018.12.002197

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Depression is one of the most prevalent mental disorders and one of the main causes of disability worldwide. Depression is a risk factor for suicide and many severe somatic diseases [1]. Morbidity of depression is increasing. In the mid-1990s, the World Bank predicted that in 2020 depression would rank second after cardiovascular diseases among the leading causes of disability [2]. Depression is also the most expensive of all brain diseases [3]. Thus, depression now is a very complicated medical and social problem that in the next few years will be only exacerbate. Therefore, investigation of all aspects of pathogenesis of depression is one of the most important problems of the medicine.

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