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Genotype and Allele Frequencies of CYP2C9, VKORC1, CYP2C19 and PON1 in Chinese Han Population Detected in our Hospital

Volume 12 - Issue 1

Keguang Chen, Rui Zhang, Nan Guo and Rui-chen Guo*

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    • Institute of Clinical Pharmacology, Qilu Hospital of Shandong University, China
    • *Corresponding author: Rui-chen Guo, Institute of Clinical Pharmacology, Qilu Hospital of Shandong University, Jinan, China

Received: December 05, 2018;   Published: December 12, 2018

DOI: 10.26717/BJSTR.2018.12.002185

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Warfarin and clopidogrel are commonly used anticoagulant and antiplatelet drugs, and their response and/or toxicity were significant influenced by genetic polymorphism of drug metabolizing enzymes transporters and drug targets. Different human populations can differ significantly in genetic allelic frequencies of these enzymes. This paper focuses on genotype and allele frequencies of genes which affect the pharmacokinetic and pharmacodynamic of warfarin or clopidogrel in Han Chinese population detected in our hospital, to provide guidance for the application of pharmacogenomics and clinical pharmacology.

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