*Corresponding author:Nasrin Akther, Department of Pharmacy, BGC Trust University Bangladesh, Bangladesh
Received: October 06, 2018; Published: October 22, 2018
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Breast cancer is an increasing public health problem. One of the main causes of breast cancer is estrogen receptor alpha. Over expression of estrogen receptor is seen in number of cases of breast cancer. The aim of this study was to screen out the effective bioactive compounds from Phyllanthus emblica namely 1,1-diphenyl-2-picrylhydrazyl, isocorilagin, kaempferol, kaempferol 3-bita-D-glucopyranoside and quercetin which may be potential inhibitors of estrogen receptor alpha (ER-α) for searching a drug against the breast cancer. A wide range of docking score found during molecular docking by Schrodinger. Among all the compounds isocorilagin showed best docking score towards estrogen receptor alpha. So, isocorilagin is the best compounds for selective inhibitors of estrogen receptor alpha, as it possessed best value in Molecular docking. Further in vitro and in vivo investigation need to identify estrogen receptor alpha inhibitory activity of isolated compounds from Phyllanthus emblica.
Keywords: Breast Cancer; Estrogen Receptor Alpha (ER-α); Phyllanthus Emblica; Molecular Docking; Isocorilagin