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Research ArticleOpen Access

In Silico Molecular Docking Approch of Some Selected Isolated Phytochemicals from Phyllanthus Emblic Against Breast Cancer

Volume 10 - Issue 2

Shanta Afrin 1, Nazim Uddin2, Kazi Zahra Mehjabin3, Tarannur Kabir Niketa4, Fayejun Nesa4, Shermin Akther4, Sahida Akther4, Sajal Chakraborty4, Dipannita Chowdhury4 and Nasrin Akther*4

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    • 1Chittagong Medical College, Faculty of Medicine, University of Chittagong, Bangladesh
    • 2Department of Pharmacy, Southern University, Bangladesh
    • 3Department of Pharmacy, North South University, Bangladesh
    • 4Department of Pharmacy, BGC Trust University Bangladesh, Bangladesh
    • *Corresponding author: Nasrin Akther, Department of Pharmacy, BGC Trust University Bangladesh, Bangladesh

Received: October 06, 2018;   Published: October 22, 2018

DOI: 10.26717/BJSTR.2018.10.001917

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Abstract

Breast cancer is an increasing public health problem. One of the main causes of breast cancer is estrogen receptor alpha. Over expression of estrogen receptor is seen in number of cases of breast cancer. The aim of this study was to screen out the effective bioactive compounds from Phyllanthus emblica namely 1,1-diphenyl-2-picrylhydrazyl, isocorilagin, kaempferol, kaempferol 3-bita-D-glucopyranoside and quercetin which may be potential inhibitors of estrogen receptor alpha (ER-α) for searching a drug against the breast cancer. A wide range of docking score found during molecular docking by Schrodinger. Among all the compounds isocorilagin showed best docking score towards estrogen receptor alpha. So, isocorilagin is the best compounds for selective inhibitors of estrogen receptor alpha, as it possessed best value in Molecular docking. Further in vitro and in vivo investigation need to identify estrogen receptor alpha inhibitory activity of isolated compounds from Phyllanthus emblica.

Keywords: Breast Cancer; Estrogen Receptor Alpha (ER-α); Phyllanthus Emblica; Molecular Docking; Isocorilagin

Abstract | Introduction| Methods and Materials| Result| Discussion| Conclusion| Acknowledgment| References|