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ISSN: 2574 -1241
ISSN: 2574 -1241
Received: September 28, 2018; Published: October 04, 2018
DOI: 10.26717/BJSTR.2018.09.001824
Wnts are secreted lipid-modified glycoproteins in most mammalian genomes. Wnt ligands are the essential components of Wnt signaling pathways. Before binding to specific receptors, Wnt proteins experienced post-translational modification of acylation and N-glycosylation mediated by acyltransferase porcupine. Mature Wnts are transported from the Golgi to plasma membrane under association with Wntless. Retromer complex, P24 and other molecules are all involved in the secretion and release of Wnts. In this review, we provide an update of the post-translational modification, secretion and release of Wnts.
Keywords: Wnts; Acylation; N glycosylation; Wntless; Retromer
International Association of Landscape Archaeology, Czech Glass Society, Czech Republic
Department of Chemistry, Semenov Institute of Chemical Physics, USSR Academy of Sciences, Moscow, Russia
Pharmaco-kinetics, dynamics and Drug Metabolism, Touro College of Pharmacy, USA
Professor of Nuclear Medicine, Faculty of Medicine and Surgery, University of Milan, Milan, Italy
Associate Professor at Department of Breast and Thyorid Surgey, Chongqing General Hospital, China
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