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Short CommunicationOpen Access

Intranasal Spray of Oxytocin Might Improve Working Memory Performance in Alzheimer, Tracking with Diffusion Tensor Imaging

Volume 9 - Issue 3

Darvishi A1, Pourmennati B1, Ghanbari Kordkandi Z1, Gharibzadeh Sh2 and Fatemeh Bakouie*2

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    • 1 Student Scientific Research Center (SSRC), Tehran University of Medical Sciences, Iran
    • 2 Institute for Cognitive and Brain Sciences (ICBS), Shahid Beheshti University, Iran

    *Corresponding author: Fatemeh Bakouie, Institute for Cognitive and Brain Sciences (ICBS), Shahid Beheshti University, Iran

Received: September 26, 2018;   Published: October 03, 2018

DOI: 10.26717/BJSTR.2018.09.001818

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Abstract

Alzheimer’s disease, neurodegenerative process, manifests as episodic memory loss and working memory impairment. Oxytocin affects dopamine and GABA releasing- modifier transmitters in working memory in prefrontal cortex, the center of working memory. Diffusion Tensor Imaging (DTI) is an MRI analyze method which can be used for tractography. We suggest that intranasal Oxytocin administration might improve working memory function which can be determined by tractography with DTI in these patients.

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