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Current Therapeutic Strategies of Parkinson’s Disease

Volume 8 - Issue 5

Poonkuzhali K and Jeevaratnam K*

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    • Department of Biochemistry and Molecular Biology, Pondicherry University, India

    *Corresponding author: Jeevaratnam K, Department of Biochemistry and Molecular Biology, Pondicherry University, Kalapet, India, Tel: 9486664762; Email: jeevskj@gmail.com

Received: September 07, 2018;   Published: September 11, 2018

DOI: 10.26717/BJSTR.2018.08.001729

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Abstract

Advances in neurosciences, imaging techniques, magnetoencephalography and mathematical modelling enlightening us how our multi- billion neurons located in different parts of our brain integrate and interact synchronously in a concerted manner to enable us to exist not only biologically but in a conscious state of Mind process. Thalamocortical rhythm, resonance and cognitive, emotional and motor binding may give us the cue. This not only provide a basis for further understanding and research in neurocognitive science but may also provide new therapeutic insights into the management of previously difficult to treat neurological and psychiatric disorders. The cerebral cortex, thalamus and the primitive involuntary motor region like the olive and the cerebellum, albeit distantly located in the brain of Homo-sapiens has multiple, parallel excitatory and inhibitory interconnective neuronal synapses enabling an efficient integrated binding of motor, perceptual, cognitive and emotional function fundamental for our survival in a conscious state [1].

Abbreviations: t -DCS: Transcranial Direct Current Stimulation; r-TMS: Repetitive Transcranial Magnetic Stimulation; NMN: Mismatch Negativity; TCD: Thalamocortical Dysrhythmia; Cog-EM: Cognitive Emotional macrocircuit; MEG: Magnetoencephalography; VPL: Ventral Posterolateral Nuclei; VPM: Ventral Posteromedial Nuclei; MG: Medial Geniculate; LG: Lateral Geniculate; VL: Ventral Lateral; VAN: Ventral Anterior Nucleus

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