Bone Marrow Stem Cell Paracrine Factors and Their Role in the Restoration of Damaged Tissues and Organs

Zurab Kakabadze¹, Nodar Kipshidze² and Nicholas Kipshidze³*

Received: August 23, 2018;   Published: September 05, 2018

DOI: 10.26717/BJSTR.2018.08.001699

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Abstract

This mini review focuses on the freeze-dried bone marrow stem cell paracrine factors and their role in the restoration of damaged tissues and organs. Recently, many authors report that freeze-dried bone marrow stem cells paracrine factors stimulate tissue regeneration via effects on cell homing/targeting, neovascularization, anti-inflammatory effects, and endogenous cell stimulation. A review of the literature demonstrated that bone marrow stem cells, following freeze-drying, preserved the function of paracrine factors and provided stronger and more durable effects on cellular proliferation, survival, and wound regeneration compared to a fresh medium or other types of synthetic growth factors. Conducting preliminary clinical investigations indicated that biologically active bone grafts containing freeze-dried bone marrow stem cell paracrine factors may be used for the reconstruction of large mandible bone defects following tumor resection. Despite the encouraging results obtained, it is too early to talk about the possibility of using freeze-dried bone marrow stem cell paracrine factors in clinical practice. Further experimental and clinical studies with greater rigor are needed to determine the effectiveness of using freeze-dried bone marrow stem cell paracrine factors.

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