Research ArticleOpen Access

Artemisinin Derivatives Based Therapeutic Combinations for the Treatment of Uncomplicated Plasmodium Falciparum Malaria: Find-Ings of a Meta-Analysis of Surveys Carried Out in Senegal

Volume 8 - Issue 4

Papa Ndiaye*¹, Annie Wassiatou Abiola², Roger Clement Tine², Kouvidjin Ekoue², Coumba Cisse², Khadime Sylla², Doudou Sow², Ibrahima Diallo³, Thwing J⁴, Jean Louis Ndiaye², Magatte Ndiaye², Aminata Collé Lo², Oumar Gaye² and Babacar Faye²

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- ¹Section Santé Publique, Unité de Formation et de Recherche des sciences de la Santé (UFR2S), Université Gaston Berger (UGB) Saint-Louis, Sénégal
- ²Service de Parasitologie - Mycologie, Faculté de Médecine, Pharmacie et Odontologie, UCAD, Sénégal
- ⁴Programme National de Lutte contre le Paludisme, Ministère de la Santé et de l’Action Sociale, Sénégal
- ⁵USAID PMI, Sénégal
*Corresponding author: Papa Ndiaye, Section Santé Publique, Unité de Formation et de Recherche des sciences de la Santé (UFR2S), Université Gaston Berger (UGB) Saint-Louis, Senegal

Received: July 07, 2018; Published: August 31, 2018

DOI: 10.26717/BJSTR.2018.08.001674

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Abstract

Objectives: The objective of this study was to analyze studies comparing efficacy of various Artemisinin-based combination therapies (ACTs).

Study Design: Meta-analysis of 11 selected studies: 10 were comparative with AL and 1 without AL.

Method: The patient groups were comparable at the inclusion. Patients were followed for 28 days (D) according to the WHO protocol with regular clinical and laboratory evaluations.

Results: Very good efficacy (>95%) were obtained at D28, for all the combinations tested, with no statistically significant difference. The total clearance of fever was obtained at D3 for all patients. The fever was more persistent at D2 in children with ASAQ and ASMQ than in those with AL. Parasitic clearance was better for all ACTs than for AL, except for DHPQTMP. At D2, gametocyte carriage was similar for the treatment groups analyzed. Side effects were more marked in patients treated with ASMQ than in those on AL.

Conclusion: ACTs are of great benefit in the management of uncomplicated P. falciparum malaria. The ASAQ, ASMQ, DHAPQ and DHPQTMP associations are as effective and well tolerated as the AL association.