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The Functional Link between AMPK Pathway Activation and Atherosclerosis Progression

Volume 8 - Issue 3

Kholoud Alaa El Mihia*

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- Department of Biochemistry, Faculty of Pharmacy, Mansoura University, Egypt
*Corresponding author: Kholoud Alaa El Mihi, Department of Biochemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt

Received: August 18, 2018; Published: August 29, 2018

DOI: 10.26717/BJSTR.2018.08.001664

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Abstract

The atherosclerosis is a complex pathological process that influences lipid deposition in the intima of middle- and large-sized arteries. AMP-activated protein kinase (AMPK) is a nutrient sensor that stimulates ATP production and fatty acid oxidation but inhibits lipogenesis. Moreover, AMPK plays a key role in regulating oxidative stress, inflammation and vascular smooth muscle cells de-differentiation involved in atherosclerosis progression.

Keywords: Atherosclerosis; Oxidative Stress; AMPK; Dyslipidemia

Abbreviations: ACC: Acetyl COA Carboxylase; AMPK: AMP-Activated Protein Kinase; ECM: Extracellular Matrix; LDL: Low-Density Lipoprotein; NO: Nitric Oxide; NOX: NADPH Oxidase; VSMCs: Vascular Smooth Muscle Cells

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