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ISSN: 2574 -1241
ISSN: 2574 -1241
Received: August 18, 2018; Published: August 29, 2018
DOI: 10.26717/BJSTR.2018.08.001664
The atherosclerosis is a complex pathological process that influences lipid deposition in the intima of middle- and large-sized arteries. AMP-activated protein kinase (AMPK) is a nutrient sensor that stimulates ATP production and fatty acid oxidation but inhibits lipogenesis. Moreover, AMPK plays a key role in regulating oxidative stress, inflammation and vascular smooth muscle cells de-differentiation involved in atherosclerosis progression.
Keywords: Atherosclerosis; Oxidative Stress; AMPK; Dyslipidemia
Abbreviations: ACC: Acetyl COA Carboxylase; AMPK: AMP-Activated Protein Kinase; ECM: Extracellular Matrix; LDL: Low-Density Lipoprotein; NO: Nitric Oxide; NOX: NADPH Oxidase; VSMCs: Vascular Smooth Muscle Cells
Abstract | Introduction | References |
International Association of Landscape Archaeology, Czech Glass Society, Czech Republic
Department of Chemistry, Semenov Institute of Chemical Physics, USSR Academy of Sciences, Moscow, Russia
Pharmaco-kinetics, dynamics and Drug Metabolism, Touro College of Pharmacy, USA
Professor of Nuclear Medicine, Faculty of Medicine and Surgery, University of Milan, Milan, Italy
Associate Professor at Department of Breast and Thyorid Surgey, Chongqing General Hospital, China
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