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ISSN: 2574 -1241
ISSN: 2574 -1241
Received: August 18, 2018; Published: August 29, 2018
DOI: 10.26717/BJSTR.2018.08.001664
The atherosclerosis is a complex pathological process that influences lipid deposition in the intima of middle- and large-sized arteries. AMP-activated protein kinase (AMPK) is a nutrient sensor that stimulates ATP production and fatty acid oxidation but inhibits lipogenesis. Moreover, AMPK plays a key role in regulating oxidative stress, inflammation and vascular smooth muscle cells de-differentiation involved in atherosclerosis progression.
Keywords: Atherosclerosis; Oxidative Stress; AMPK; Dyslipidemia
Abbreviations: ACC: Acetyl COA Carboxylase; AMPK: AMP-Activated Protein Kinase; ECM: Extracellular Matrix; LDL: Low-Density Lipoprotein; NO: Nitric Oxide; NOX: NADPH Oxidase; VSMCs: Vascular Smooth Muscle Cells
Abstract | Introduction | References |
International Association of Landscape Archaeology, Czech Glass Society, Czech Republic
Department of Chemistry, Semenov Institute of Chemical Physics, USSR Academy of Sciences, Moscow, Russia
Pharmaco-kinetics, dynamics and Drug Metabolism, Touro College of Pharmacy, USA
Professor of Nuclear Medicine, Faculty of Medicine and Surgery, University of Milan, Milan, Italy
Clinical Radiologist (MD) - Department of RADIOLOGY, Cosenza Hospital, Cosenza, Italy
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