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ISSN: 2574 -1241
ISSN: 2574 -1241
Received: August 11, 2018; Published: August 21, 2018
DOI: 10.26717/BJSTR.2018.08.001616
Objective: To evaluate the effects of low-level laser therapy and extract of Calendula officinalis Linn. (calendula), alone or in combination, on cutaneous wound healing in rats.
Setting: A university research center.
Design: A prospective, interventional, randomized, controlled experimental study. Forty-eight female Wistar rats, aged 3 to 4 months, were divided into 4 groups of 12 animals each. A skin wound was surgically made in the dorsal region of each animal and treated for 21 days with either low-level laser therapy (laser group), calendula extract gel (calendula group), laser therapy combined with calendula extract gel (laser + calendula group) or received no treatment (control group). Data collection was performed immediately after surgery and on postoperative days 3, 6, 9, 12, 15, 18 and 21.
Main Outcome Measures: Measurement of the wound area was performed by tracing the contour of the wound on a sterile polypropylene film placed over the wound. The drawing was transferred to the Auto Cad software to determine the size of the wound area.
Results: No significant differences in wound area size were found among groups up to the postoperative day 6. After 9 days of treatment, the laser group showed a significantly greater reduction in wound area compared to the other groups.
Conclusion: Laser therapy alone contributed more to wound healing in rats than the treatment with calendula extract gel alone or combined with laser therapy
Keywords: Laser; Calendula Officinalis; Healing; Surgical Wound
The effects of low-level laser therapy and extract of Calendula officinalis Linn. (calendula), alone or in combination, on cutaneous wound healing in rats were evaluated in 48 Wistar rats. Low-level laser therapy alone contributed more to wound healing in rats than the treatment with calendula extract, alone or in combination. The effect of low-level laser therapy and extract of Calendula officinalis Linn. on cutaneous wound healing in rats
Abstract | Introduction | Methods | Results | Discussion | Conclusion | References |
International Association of Landscape Archaeology, Czech Glass Society, Czech Republic
Department of Chemistry, Semenov Institute of Chemical Physics, USSR Academy of Sciences, Moscow, Russia
Pharmaco-kinetics, dynamics and Drug Metabolism, Touro College of Pharmacy, USA
Professor of Nuclear Medicine, Faculty of Medicine and Surgery, University of Milan, Milan, Italy
Associate Professor at Department of Breast and Thyorid Surgey, Chongqing General Hospital, China
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