Association of Brain-derived Neurotrophic Factor (BDNF) Gene SNPs G196A and C270T with Parkinson’s disease: A Meta- Analysis

Shovit Ranjan¹ and Praveen Kumar Sharma*²

Received: June 22, 2018;   Published: June 27, 2018

DOI: 10.26717/BJSTR.2018.06.001314

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Abstract

Introduction: Brain-derived neurotrophic factor (BDNF) plays a key role in promoting the survival of neurons in the nervous system. Polymorphism in the gene region 196G>A and 270C>T of BDNF has been studied for susceptibility to Parkinson’s Disease (PD) but results from different studies are inconclusive.

Objective: To carry out a meta-analysis and trial-sequential analysis of the previous studies to assess the relationship between the BDNF 196G>A and 270C>T polymorphism and PD risk.

Methods:The databases were searched for the studies concerning BDNF 196G>A and 270C>T polymorphism and its association with PD risk. The pooled odds ratios (ORs) along with 95% confidence intervals (95% CIs) were calculated for all the genetic models, from the selected case-control studies, by meta-analysis. The required information size was calculated using α = 0.05 (two sided), β = 0.20 (power 80%) and a relative risk reduction of 20%, by using trial sequential analysis (TSA)

Results: Results of present meta-analysis identified an association between recessive AA Vs GG+AG genotype and PD in Asian population but no association between BDNF 196 G/A polymorphism and PD in European population. On the other hand, association between BDNF 270 C/T allele in overall studies was observed for T Vs C allelic contrast and dominant TT+TC Vs CC genotype.

Conclusion: Our meta-analysis demonstrate that the evidence for associations between BDNF polymorphisms (G196A and C270T) and PD risk for few allele and genotype combinations are present but is ethnicity dependent.

Keywords: BDNF; G196A; C270T; Parkinson’s Disease; Polymorphism; Meta-Analysis; Trial Sequential Analysis

Abstract| Introduction| Materials and Methods| Results| Discussion| Conclusion| Acknowledgement| References|