Display Pertussisin Pregnant Women in East Azerbaijan of Iran, Need to Improve Vaccination Strategies

Roqieh Babaei¹, Ali Badamchi², Hamide Hassanpour² and Jalal Shayegh*³

Received: June 14, 2018;   Published: June 21, 2018

DOI: 10.26717/BJSTR.2018.05.001278

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Abstract

Introduction: Pertussis, a respiratory infection caused by the bacteria Bordetella pertussis, can affect persons of any age, but it is particularly virulent and life-threatening in infants. Rates of pertussis infection have been increasing in recent years.

Methods: In this study, levels of IgG-PT and IgA-PT antibodies was analyzed in 349 serum samples obtained from pregnant women in east Azerbaijan (Tabriz city) using ELISA.

Results: Based on the results of ELISA, 56.2% of the serum samples had a protective level of IgG. The result was 21(6%) for IgA from the total 349 serum samples. About the relation between protective levels of antibody titers with age, occupation, history of coughing, education level, and pregnancy stage, there was a significant correlation between the protective levels of antibodies and the history of cough. The results due to IgG level indicate a drop in the immune level affected by the vaccine and the need to strengthen immunity in the study area. The level of IgA antibodies may indicate the rate of new infections in the studied population.

Conclusion: An outbreak among adults is a warning and risk factor for the development and spread of infection in newborns.

Keywords: Immunoglobulin Levels; Bordetella Pertussis; Pregnant Women; Iran

Abstract| Introduction| Materials and Methods| Results| Discussion| References|