info@biomedres.us   +1 (502) 904-2126   One Westbrook Corporate Center, Suite 300, Westchester, IL 60154, USA   Site Map
ISSN: 2574 -1241

Impact Factor : 0.548

  Submit Manuscript

Research ArticleOpen Access

Concise Review: Knee Cartilage Repair Techniques using Cellular Therapy

Volume 5 - Issue 4

Coursier R1,2, Mazor M1, Best TM4, Lespessailles E1,3 and Toumi H1,3

  • Author Information Open or Close
    • 1Treatment and Prevention of Osteoporosis, University of Orleans, France
    • 2Department of Orthopaedic Surgery, Hospital Group of the Catholic Institute of Lille (GHICL), France
    • 3Rheumatology Service, Orléans Regional Hospital Center, France
    • 4UHealth Sports Medicine Institute, University of Miami Miller School of Medicine, USA

    *Corresponding author: Hechmi Toumi, Vice-Director Laboratory EA-I3MTO, University of Orléans, Vice-President of the Institute of Research, Treatment and Prevention of Osteoporosis, CHR d’Orléans

Received: June 07, 2018;   Published: June 14, 2018

DOI: 10.26717/BJSTR.2018.05.001226

Full Text PDF

To view the Full Article   Peer-reviewed Article PDF

Abstract

Osteoarthritis is a degenerative disease of joints and leading cause of joint pain resulting from subchondral bone hypertrophy and inflammation. Although, many researches have been focused to overcome the articular cartilage, the latter has proven to be a very difficult tissue to repair defeating researchers, surgeons, and patients. Numerous surgical techniques have been developed to address focal cartilage defects. One area that seems encouraging is cell-based therapies based on stem cells to promote cartilage repair. Several human body tissues contain mesenchymal stem cells from where these can be harvested and cultured. This review summarises autologous chondrocytes implantation, first generation, second generation, third generation and recent clinical trials on mesenchymal stem cells implantation.

Keywords: Osteoarthritis; Cartilage; Chondrocytes Implantation; Mesenchymal Stem Cells

Abstract| Introduction| Conclusion| References|