Aromatic Aldehydes and Carboxylic Acids as inhibitors for Sickle Hemoglobin Polymerization

Ahmed S Mehanna* and Omeima Abdullah

Received: February 28, 2018;   Published: March 27, 2018

DOI: 10.26717/BJSTR.2018.03.000890

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Abstract

The reported inhibitory effects of the natural products vanillin and 5-hydroxymethylfurfural prompted us to assess the anti-polymerization activities of several structurally related aromatic aldehydes and carboxylic acids. In addition to vanillin and 5-hydroxymethylfurfural, eleven more structurally related aromatic aldehydes and carboxylic acids including 2,4-dihydroxy benzaldehyde, furfural, 3-furfural, 5-methylfurfural, vanillic acid, 2-hydroxy-3-methoxy-benzoic acid, homovanillic acid, mandelic acid, 4-hydroxy-3-methoxy-mandelic acid, 4-bromo-mandelic acid and4-trifluromethyl-mandemic acid are evaluated for activity using our newly reported high throughput kinetic assay designed to study sickle cell hemoglobin polymerization kinetics. Several of the tested compounds exhibited promising anti-polymerization activities, comparable to that of vanillin and 5-hydroxymethylfurfural, includinghomovanillic acid, mandelic acid, 3-hydroxy-3-methoxymandelic acid, and 3-furfural. The structure activity relationship of all tested compounds is included.

Keywords: Sickle Cell Anemia; Sickle Hemoglobin; Homovanillic Acid; Mandelic Acid; Vanillin, Furfural

Abbreviations: SCA: Sickle cell anemia; HbA: Hemoglobin Molecule; HbS: Sickle Hemoglobin;

Abstract| Introduction| Results and Discussion| Conclusion| Acknowledgment| References|