*Corresponding author:Karthik D Yadav, Post Graduate student, Department of oral medicine and radiology, The oxford dental college and research center, 10th Milestone, Bommanahalli, Bangalore-560102, India; Tel: 919902824646; Email: firstname.lastname@example.org
Received: December 20, 2017; Published: January 04, 2018
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Oral squamous cell carcinoma is the sixth most common malignant neoplasm worldwide. Each year it accounts for more than 300,000 cases worldwide. The 5-year survival rate for OSCC has remained at approximately 50% for the past several decades . The impact of oral cancer is such that the disease and its treatment bring a heavy financial burden to both the social resources and the patient’s family with psychological stress affecting the quality of life . It develops through a multistep process of genetic, epigenetic and metabolic changes resulting from exposure to carcinogens, with initially the presence of a precursor/pre-cancer such as oral leukoplakia, oral erythroplakia oral submucous fibrosis. The most frequently reported etiological agents being tobacco, alcohol, chewing of betel quid containing areca nut . The global incidence of oral submucous fibrosis is estimated at 2.5 million individuals.