Oral Submucous Fibrosis: the Soft Tissue Marble of Asia

Karthik D Yadav¹*and PaiAnuradha²

Received: December 20, 2017;   Published: January 04, 2018

DOI: 10.26717/BJSTR.2018.02.000629

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Abstract

Oral squamous cell carcinoma is the sixth most common malignant neoplasm worldwide. Each year it accounts for more than 300,000 cases worldwide. The 5-year survival rate for OSCC has remained at approximately 50% for the past several decades [1]. The impact of oral cancer is such that the disease and its treatment bring a heavy financial burden to both the social resources and the patient’s family with psychological stress affecting the quality of life [2]. It develops through a multistep process of genetic, epigenetic and metabolic changes resulting from exposure to carcinogens, with initially the presence of a precursor/pre-cancer such as oral leukoplakia, oral erythroplakia oral submucous fibrosis. The most frequently reported etiological agents being tobacco, alcohol, chewing of betel quid containing areca nut [3]. The global incidence of oral submucous fibrosis is estimated at 2.5 million individuals.

Introduction| Aetiopathogenesis| Clinical Features| Diagnosis & Investigations| Management| References|