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Research ArticleOpen Access

Silica Chloride Catalyzed Efficient Synthesis of 2,3-Dihydroquinazoline-4(1h)-Ones Derivatives In Water

Volume 1 - Issue 6

Suvarna Lavale and Milind Ubale*

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    • Post graduate department of Chemistry, Vasantrao Naik College, India

    *Corresponding author: Milind Ubale, Post graduate department of Chemistry, Vasantrao Naik College, Aurangabad, India

Received: November 07, 2017;   Published: November 29, 2017

DOI: 10.26717/BJSTR.2017.01.000549

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Abstract

Describe method consist of eco-friendly procedure for the preparation of 2,3-dihydroquinazoline-4(1H)-ones from equimolar 2-aminobenzamide and substituted aromatic aldehydes in presence of 20mol% of silica chloride. Green impact of reaction significantly enhanced due to use of water as solvent and recyclable silica-chloride as catalyst. Good to excellent yield of products, simple working strategy and easy purification are the advantage of present methodology

Keywords: Quinazoline; Silica-chloride catalyst; Water mediated; Green methodology

Abstract| Introduction| Experimental| Results and Discussions| Conclusion| References|