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Is Low Grade Infection a Contributing Factor of Disc Degeneration?

Kalliopi Alpantaki1 and Alexander G Hadjipavlou2*

DOI: 10.26717/BJSTR.2017.01.000278

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    • 1Orthopedic Surgeon, Private Consultant, Greece
    • 2Department of Orthopaedic Surgery and Rehabilitation, University of Texas Medical Branch, Galveston, USA

      • Corresponding author: Alexander G. Hadjipavlou, Department of Orthopaedic Surgery and Rehabilitation, University of Texas Medical Branch, Galveston, Texas, USA

Received: August 09, 2017;   Published: August 17, 2017

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Abstract

Intervertebral disc degeneration (IVD) has a multi factorial origin. Genetic and environmental factors are major determinants. However the pathomechanisms of IVD is inadequately understood. Low grade infection has also been implicated, however, its scientific rigor has been questioned. This article reviews the current literature in this field. Evidence suggests that low grade infection can also be imputed as a potential causative factor of IVD and perhaps serves as a paradigm shift of our current thinking in this entity.

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