Corresponding author:Alexander G. Hadjipavlou, Department of Orthopaedic Surgery and Rehabilitation, University of Texas Medical Branch, Galveston, Texas, USA
Received: August 09, 2017; Published: August 17, 2017
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Intervertebral disc degeneration (IVD) has a multi factorial origin. Genetic and environmental factors are major determinants. However the pathomechanisms of IVD is inadequately understood. Low grade infection has also been implicated, however, its scientific rigor has been questioned. This article reviews the current literature in this field. Evidence suggests that low grade infection can also be imputed as a potential causative factor of IVD and perhaps serves as a paradigm shift of our current thinking in this entity.