Toward an Exosome-Based Therapeutic Strategy
in Regenerative Dentistry

Yeon Hee Lee; Il Keun Kwon; Jae Min Cha

doi:10.26717/BJSTR.2018.12.002190

Mini ReviewOpen Access

Toward an Exosome-Based Therapeutic Strategy in Regenerative Dentistry

Volume 12 - Issue 1

Woo Sung Son*

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- ¹Department of Orofacial Pain and Oral Medicine, Kyung Hee University, Republic of Korea
- ²Department of Dental Materials, School of Dentistry, Kyung Hee University, Republic of Korea
- ³3D-Stem Cell Engineering Laboratory, Department of Mechatronics, College of Engineering, Incheon National University, Republic of Korea

Received: December 05, 2018; Published: December 12, 2018

DOI: 10.26717/BJSTR.2018.12.002190

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Abstract

Exosomes are small extracellular vesicles of endosomal origin and have been receiving much attention in the dental field. Their role was considered to be only as a waste disposal system, but now they are emerging as a class of signal mediators. Significantly, their biochemical content includes not only lipids and proteins, but also nucleic acids, mainly miRNAs and mRNAs. They are being considered as attractive vehicles for cargo delivery to target cells. Exosomes also have regenerative and immunomodulatory properties, characteristics that are encouraging their application for regenerative dentistry. Considering the potential role of exosomes in tissue regeneration and their advantages over cell-based therapy, their applications in the dental field will continue to be studied.

Keywords :Exosome; Extracellular vesicle; Mesenchymal stem cell; Regeneration; Dentistry

Abbreviations : miRNAs: Micro RNAs; mRNAs: Messenger RNAs; MSC: Mesenchymal Stem Cell