Anticancer Attributes of Gold Nanoparticles Synthesized by Novel Isolate Streptomyces tuirus DBZ39

Bi Bi Zainab Mazhari¹*, Dayanand Agsar², Mohammed H Saiemaldahr¹, Waleed Abu AlSoud¹, Ahmad Adam¹, Amina Qaeet Alrowaily¹ and Intisar Elshek¹

Received: September 16, 2018;   Published: September 20, 2018

DOI: 10.26717/BJSTR.2018.09.001764

Full Text PDF

To view the Full Article   Peer-reviewed Article PDF

Abstract

In the present investigation, an attempt was made to explore the anticancer activity of extracellular gold nanoparticles from Streptomyces sp. The synthesized gold nanoparticles were characterized by UV-vis spectrophotometry and scanning electron microscopy. The presence of gold nanoparticles after the synthesis was examined by recording the UV-vis spectra of the solution and also by visual biomonitoring of the solution. The peaks recorded in the UV-vis spectra of the solutions was in between the wavelength of 500 to 600nm which confirms the presence of gold nanoparticles. Scanning electron microscopy reveals the synthesis of gold nanoparticles with an average size 27 to 56nm in the solution. Different concentrations of gold nanoparticles (200 - 10μl) were subjected to illustrate the anticancer activity using cell lines namely adeno carcinoma (HT 29), kidney cancer (K 293) and breast cancer (MDA 231). The percent inhibition for these cell lines was recorded and observed to be very high at 200μl. The investigation revealing the anticancer activity of gold nanoparticles has been reported for the first time. Gold nanoparticles could be used as cost effective and efficient means of future devices in medical sciences.

Keywords: Streptomyces; Gold nanoparticles; Anticancer; Cell lines

Abstract | Introduction | Materials and Methods | Results | Conclusion | References |