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ISSN: 2574 -1241
ISSN: 2574 -1241
Received: July 25, 2018; Published: August 21, 2018
DOI: 10.26717/BJSTR.2018.08.001619
Betulin is a pentacyclic triterpene alcohol with a lupane skeleton and is known to possess a broad range of biological activities, including anti-inflammatory, anti-viral and anti-cancer actions. Betulin contains primary and secondary hydroxyls that are situated in different steric environments and shows different activities. The literature concerning the pharmacological properties, the resource and isolation of betulin, the chemical synthesis of betulin and its derivatives, the biotransformation of betulin was reviewed and it will prepare for the further studies such as the structure-activity research (SAR), the pharmacological and toxicologic study.
Keywords: Triterpene; Pharmacological properties; Distribution; Chemical synthesis; Biotransformation
Abstract | Introduction | Distribution and Isolation of Betulin | Synthesis Methods of Betulin Derivatives | Conclusion | Acknowledgement | References |
International Association of Landscape Archaeology, Czech Glass Society, Czech Republic
Department of Chemistry, Semenov Institute of Chemical Physics, USSR Academy of Sciences, Moscow, Russia
Pharmaco-kinetics, dynamics and Drug Metabolism, Touro College of Pharmacy, USA
Professor of Nuclear Medicine, Faculty of Medicine and Surgery, University of Milan, Milan, Italy
Associate Professor at Department of Breast and Thyorid Surgey, Chongqing General Hospital, China
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