Review ArticleOpen Access

Research Progress in the Promissing Natural Product-Betulin

Volume 8 - Issue 2

**Qingfeng Meng¹, Xuan Zhou², Le Liu² and Shaobin Fu*^2,3**

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- ¹Department of Public Health, Zunyi Medical University, China
- ²Pharmacy School of Zunyi Medical University, China
- ³Generic Drug Research Center of Guizhou Province, Green Pharmaceuticals Engineering Research Center of Guizhou Province, China
*Corresponding author: Shao Bin FU, Generic Drug Research Center of Guizhou Province, Green Pharmaceuticals Engineering Research Center of Guizhou Province, Zunyi, 563000, China

Received: July 25, 2018; Published: August 21, 2018

DOI: 10.26717/BJSTR.2018.08.001619

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Abstract

Betulin is a pentacyclic triterpene alcohol with a lupane skeleton and is known to possess a broad range of biological activities, including anti-inflammatory, anti-viral and anti-cancer actions. Betulin contains primary and secondary hydroxyls that are situated in different steric environments and shows different activities. The literature concerning the pharmacological properties, the resource and isolation of betulin, the chemical synthesis of betulin and its derivatives, the biotransformation of betulin was reviewed and it will prepare for the further studies such as the structure-activity research (SAR), the pharmacological and toxicologic study.

Keywords: Triterpene; Pharmacological properties; Distribution; Chemical synthesis; Biotransformation