*Corresponding author:Naresh Kumar Sood, Department of Teaching Veterinary Clinical Complex, Guru Angad Dev Veterinary and Animal Sciences University, India
Received: June 25, 2018; Published: July 03, 2018
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The researchers till now have been more focused on the mechanisms of angiogenesis in tumor metastasis. The lack of specific lymphatic markers has been a constraint in establishing the role of lymphatics in tumor metastasis in the past. With the advent of few novel lymphatic markers i.e Podoplanin, Prox 1, LYVE-1, vascular endothelial growth factor receptor-3 (VEGFR-3) and its growth factors VEGF-C and VEGF-D, the research on lymphangiogenesis and lymphatics as a mode of tumor metastasis has picked up. The purpose of this mini-review is to make the researchers aware about the role played by the lymphatics and the process of lymphangiogenessis in mammary cancer metastasis.
Keywords: Lymphangiogenesis; Lymphatic Markers; Mammary Tumor Metastasis