*Corresponding author:
Ankur K Guha, Department of Chemistry, Cotton University, Guwahati, Assam, IndiaReceived: February 27, 2018; Published: March 08, 2018
DOI: 10.26717/BJSTR.2018.03.000835
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Quantum chemical calculations have been carried out using MP2/6-311++G** level of theory to calculate lipophilicity, i.e., octanol-water partition coefficient (LogP) of some alcohols and their silicon derivatives. Very good correlation has been obtained between the experimental LogP values against our calculated one. Moreover, incorporation of Si atom into the C atom attached to the -OH group dramatically increases the lipophilicity of the compounds. This finding may have wide implications towards designing new Si incorporated drugs.
Abstract| Introduction| Results and Discussions| Conclusion| Acknowledgement| References|