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ISSN: 2574 -1241
ISSN: 2574 -1241
Received: February 27, 2018; Published: March 08, 2018
DOI: 10.26717/BJSTR.2018.03.000835
Quantum chemical calculations have been carried out using MP2/6-311++G** level of theory to calculate lipophilicity, i.e., octanol-water partition coefficient (LogP) of some alcohols and their silicon derivatives. Very good correlation has been obtained between the experimental LogP values against our calculated one. Moreover, incorporation of Si atom into the C atom attached to the -OH group dramatically increases the lipophilicity of the compounds. This finding may have wide implications towards designing new Si incorporated drugs.
Abstract| Introduction| Results and Discussions| Conclusion| Acknowledgement| References|
International Association of Landscape Archaeology, Czech Glass Society, Czech Republic
Department of Chemistry, Semenov Institute of Chemical Physics, USSR Academy of Sciences, Moscow, Russia
Pharmaco-kinetics, dynamics and Drug Metabolism, Touro College of Pharmacy, USA
Professor of Nuclear Medicine, Faculty of Medicine and Surgery, University of Milan, Milan, Italy
Associate Professor at Department of Breast and Thyorid Surgey, Chongqing General Hospital, China
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