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ISSN: 2574 -1241

Research ArticleOpen Access

Research of Associations of Polymorphisms p53 and p21 with the Risk of the Carcinogenesis gastric

Volume 2 - Issue 1

AI Dmitrieva1,2, NV Sevostyanova2*, VA Serebryakova1,2 and AL Chernichova1

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    • 1Federal State Funded Educational Institution of Higher Education Siberian State Medical University of the Ministry of Healthcare of the Russian Federation, Russia
    • 2Regional Public Independent Healthcare Institution, Tomsk regional oncologic dispensary, Russia

    *Corresponding author: Sevostyanova Nataliya, Regional Public Independent Healthcare Institution, Tomsk regional oncologic dispensary, Russia; Email: sev_nv@mail.ru

Received: December 28, 2017;   Published: January 08, 2018

DOI: 10.26717/BJSTR.2018.02.000638

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Abstract

The method of a polymerase chain reaction in the mode of “real time” with hybridizationaly-fluorescent detection carried out the analysis of distribution of polymorphisms of genes p53 by G215C, p21 A1026G and G369C at patients with the gastric carcinoma and healthy donors. It is established that an allele of C, genotypes of CC and GC of polymorphisms G215C of gene p53 and gene G369C p21, an allele of A and genotypes of AA and GA of polymorphism of A1026G of gene p21 statistically are associated with the risk of carcinogenesis gastric.

Keywords: p53 G215C; p21 A1026G and G369C; Polymorphism; Regulator genes of a cell cycle; Gastric carcinoma

Abstract| Introduction| Methodology| Results| Conclusion| References|