*Corresponding author:Mohamed El Kassem Mohamed Hassouna, Chemistry Department, Faculty of Science 62514, Beni-Suef University, Beni-Suef, Egypt
Received: June 19, 2017 Published: July 03, 2017
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An indirect method has been developed for the determination of rosuvastatin calcium (RSC) in its pure form and in tablet formulations. It depends on the oxidative destruction of RSC using the oxygen flask technique or through combustion in a muffle furnace. The resulted Ca oxide after combustion is dissolved in 0.1N nitric acid and is determined by flame atomic absorption after appropriate dilution at 422.7 nm. The method succeeded in the determination of RSC in its pure form, where recoveries in the range 99.2-101.6 have been obtained, but failed in the determination of tablet formulations due to the interference of the other metals contained in inactive ingredients and excipients. Essential modifications have been introduced on the classical Schöniger method concerning the weight taken, volume of the combustion flask, volume of the absorption soln. and the flushing time which enabled the combustion of much larger weights. Further studies are under development to extend the application of the method for tablet formulations determination.
Keywords: Rosuvastatin Calcium; Indirect determination ; Oxygen flask ; Flame atomic absorption ; Calcium
Abbreviations: RSC: Rosuvastatin Calcium; OF: Oxygen Flask; DSC: Differential Scanning Calorimetry