Indirect Oxygen Flask-Atomic Absorption Spectrometric Determination of Rosuvastatin Calcium

Mohamed El Kassem Mohamed Hassouna*¹, Amal Ibrahim Abdel-Mageed² and Hafsa Omar Salem¹

DOI: 10.26717/BJSTR.2017.01.000164

Received: June 19, 2017   Published: July 03, 2017

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Abstract

An indirect method has been developed for the determination of rosuvastatin calcium (RSC) in its pure form and in tablet formulations. It depends on the oxidative destruction of RSC using the oxygen flask technique or through combustion in a muffle furnace. The resulted Ca oxide after combustion is dissolved in 0.1N nitric acid and is determined by flame atomic absorption after appropriate dilution at 422.7 nm. The method succeeded in the determination of RSC in its pure form, where recoveries in the range 99.2-101.6 have been obtained, but failed in the determination of tablet formulations due to the interference of the other metals contained in inactive ingredients and excipients. Essential modifications have been introduced on the classical Schöniger method concerning the weight taken, volume of the combustion flask, volume of the absorption soln. and the flushing time which enabled the combustion of much larger weights. Further studies are under development to extend the application of the method for tablet formulations determination.

Keywords: Rosuvastatin Calcium; Indirect determination ; Oxygen flask ; Flame atomic absorption ; Calcium

Abbreviations: RSC: Rosuvastatin Calcium; OF: Oxygen Flask; DSC: Differential Scanning Calorimetry

Introduction | Materials and Methods | Experimental | Results and Discussion | Conclusion | Acknowledgment | References | Figures | Tables |