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Case ReportOpen Access

Escherichia Coli CRISPR/CAS System Evolved with Bacteriophage: A Case Report

Volume 6 - Issue 1

Chi-Dung Yang1,2,4, Hsi-Yuan Huang3, Sirjana Shrestha1,4 and Hsien-Da Huang*1,4

  • Author Information Open or Close
    • 1Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Taiwan
    • 2Institute of Population Health Sciences, National Health Research Institutes, Taiwan
    • 3Department of Laboratory Medicine, China Medical University Hospital, Taiwan
    • 4Department of Biological Science and Technology, National Chiao Tung University, Taiwan

    *Corresponding author: Hsien-Da Huang, Professor of Bioinformatics, computational biology, and systems Biology College of Biological Science and Technology, National Chiao Tung University, Hsin-Chu, Taiwan

Received: June 18, 2018;   Published: June 25, 2018

DOI: 10.26717/BJSTR.2018.06.001292

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Abstract

Background: Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) is a part of an adaptive immune system in prokaryotes and occurring in diverse forms of bacteria.

Case Presentation: We presented the results of sequence analysis which can help in understanding the presence of CRISPR-mediated antiphage ability in both pathogenic and non-pathogenic strains of Escherichia coli.

Conclusion: Endogenous CRISPR spacers with imperfect matches are the candidates of anti-phage function in genetically distant strains of E. coli.

Keywords: CRISPR/Cas system; Bacteriophage; Escherichia Coli; Spacers

Abbrevations: CRISPR: Clustered Regularly Interspaced Short Palindromic Repeats; CAS: CRISPR-Associated Protein

Abstract| Background| Case Presentation| Discussion| Conclusion| References|