Effect of Hyperlipidemia on Cell Mediated Immunity; Could it be as Predisposing Factor of Cancer Risk?

Zeinab Emruzi¹, Pegah Babaheidarian², Mahmoud Arshad³ and Ghasem Ahangari*¹

Received: November 29, 2018;   Published: December 13, 2018

DOI: 10.26717/BJSTR.2018.12.002199

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Abstract

Background: The relationship between obesity and some diseases proposes a main interaction among the host lipid metabolism and immune system. On the other hand, inflammation and remarkably cytokines play a key role in defense against pathogenesis and tumor initiation.

Objective: In this project, we aim to investigate the effects of hyperlipidemia on Th1 differentiation, expression of Th1 secreted cytokines and the risk of cancer.

Methods: PBMCs were isolated from whole blood of 40 hyperlipidemia patients and 40 normal volunteers. After synthesizing cDNAs from total mRNAs, real-time PCR was performed for IL-2, IFN-γ, TNF-α cytokines, T-bet transcription factor and β-actin (as an internal control). The expression ratios were analyzed in hyperlipidemia patients in comparison with the normal group.

Results: statistically significant decrease was shown at the mRNA expression level of IL-2, IFN-γ, TNF-α and T-bet genes in hyperlipidemia patients (P≤ 0.006).

Conclusion: High level cholesterol and LDL leads to decreased expression of Th1 related cytokines, weakened cell mediated immunity and increase risk of cancer in hyperlipidemia patients.