In Vitro Tensile Properties, Hydrolytic and Oxidative Permeability of the Biomedical Thermoplastic Polyurethane (TPU) / Organohectorite Nanocomposites

Azlin Fazlina Osman*¹ and Darren Martin²

Received: November 16, 2018;   Published: November 29, 2018

DOI: 10.26717/BJSTR.2018.11.002120

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Abstract

In this work, poly(dimethylsiloxane) (PDMS) / poly (hexamethylene oxide) (PHMO)-based thermoplastic polyurethane (TPU) nanocomposites incorporating nano-organo-hectorite were studied for biomedical application. This involved the investigation on the effects of oxidative and hydrolytic exposure on the performance of the host TPU and TPU-organohectorite nanocomposites through in vitro tensile and permeability tests (in water and hydrogen peroxide (H2O2). Results demonstrated that the presence of nanosized organically modified hectorite (nano-organohectorite), either in single or dual modification system affects the in vitro tensile properties, hydrolytic and oxidant permeability of this TPU. Specifically, the TPU incorporating with the most hydrophobic nanofiller (organohectorite surface modified with 75% dimethyldioctadegylamminium chloride (DODMAC) / 25% choline) exhibits the largest increment in the modulus of elasticity, retention in water and hydrogen peroxide (H2O2) permeability upon four weeks of exposure at 37 °C due to enhanced compatibility between the nanofiller and the hydrophobic PDMS soft segments.

Keywords : Thermoplastic Polyurethane; Nano-Organofluoromica, Nano-Organohectorite; Nanocomposites; In Vitro Mechanical Properties; Permeability

Abbreviations : PDMS: Poly Dimethylsiloxane; PHMO: Poly Hexamethylene Oxide; TPU: Thermoplastic Polyurethane; DODMAC: Dimethyldioctadegylamminium Chloride; BDO: 1,4 Butanediol; MDI: 4,4’-Methylene Diphenyl Diisocyanate; ODTMA: Octadecyltrimethyl Ammonium