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Research ArticleOpen Access

Terrein and Butyrolacton VII, Antibiotically Active Compounds from Symbiotic Fungus Aspergillus Terreus Isolated from Ascidian Didemnum Molle

Volume 9 - Issue 4

Robert A Bara*1, Calvyn Sondak1, Fitje Losung1, Remmy E Mangindaan1, Jimmy Posangi2, Stefan Kehraus3, Alexander Bogdanov3, Ekaterina Egorova3 and Gabrielle Koenig3

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    • 1Faculty of Fisheries and Marine Science, Sam Ratulangi University, Indonesia
    • 2Faculty of Medicine, Sam Ratulangi University Jl. Kampus Bahu, Indonesia
    • 3Institute for Pharmaceutical Biology, University of Bonn, Germany

    *Corresponding author: Robert A Bara, Faculty of Fisheries and Marine Science, Sam Ratulangi University, Indonesia

Received: September 17, 2018;   Published: October 05, 2018

DOI: 10.26717/BJSTR.2018.09.001834

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Abstract

We performed the study of secondary metabolites from endophytic fungus Aspergillustereus. The fungus was isolated from the ascidian Didemnummolle which grow in the Malalayang waters, North Sulawesi. Chemical investigation of extracts from Biomaltagar found compounds from lactone groups namely Terrein and Butyrolacton VII. The structure of the above compounds was characterized based on spectroscopic data including NMR, UV, IR and MS. Terein and Butyolacton VII showed a narrow spectrum antibacterial activity against Gram positive bacteria Bacillus megaterium DSM32T. So far there was no reports about the antibacterial activity of Butyolacton VII.

Abstract | Introduction | Experimental Sections| Result and Discussion| Conclusion| References|