Mini ReviewOpen Access

Therapeutic Effects of BNP in Heart Failure, Good or Bad?

Volume 8 - Issue 1

Yuting Zhai¹, Yanfeng Ma², Rongsheng Kan² and Dongye Li¹*

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- ¹Institute of Cardiovascular Disease Research, Xuzhou Medical University, PR China
- ²Department of Cardiology, The Affiliated Hospital of Xuzhou Medical University, PR China
- The first two authors contributed equally to the paper.
*Corresponding author: Dongye Li, Institute of Cardiovascular Disease Research, Xuzhou Medical University, 84 West Huaihai Road, 221002, China

Received: July 30, 2018; Published: August 17, 2018

DOI: 10.26717/BJSTR.2018.08.001606

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Abstract

The natriuretic peptide system plays a critical role in the maintenance of cardiovascular homeostasis. Since the natriuretic peptides were discovered more than 2 decades ago, B-type natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) has become the most interesting biomarkers in diagnosis, risk stratification, and management of patients with heart failure (HF). More importantly, with the deepening of understanding of physiological and pathophysiological effects of BNP, increasing biological effects of BNP has been considered to be an attractive approach for treating HF. However, treatment effects of BNP in patients with both acute and chronic HF in various clinical trials have demonstrated different results. The biology of BNP is complex, there are many important issues not yet elucidated. In this review, we will focus on the the diversity of therapeutic effects of BNP in HF and give directions for the future studies.

Abbreviations: HF: Heart Failure; BNP: B-type Natriuretic Peptide; CGMP: Cyclic Guanosine Monophosphate; HFREF: Heart Failure with Reduced Ejection Fraction; NT-ProBNP: N-Terminal proBNP; ASCEND-HF: Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure; PARADIGM-HF: Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortalilty and morbidity in Heart Failure