CADASIL, Migraine and Multiple Sclerosis (MS) – The Risk of Misdiagnosis, Case Report

Piotr Bogucki¹, Paulina Felczak²,Teresa Wierzba-Bobrowicz²,Halina Sienkiewicz-Jarosz³ and Urszula Fiszer¹

Received: June 25, 2018;   Published: July 05, 2018

DOI: 10.26717/BJSTR.2018.06.001344

Full Text PDF

To view the Full Article   Peer-reviewed Article PDF

Abstract

Diagnostic criteria for multiple sclerosis (MS) have been changing for years to enable easier and faster ways to confirm diagnosis especially during last decade. They lead to earlier treatment of patients with MS what gives higher likelihood to keep patients fit and capable of working. Dissemination in time (DIT) and in space (DIS) are general rules which are necessary to diagnose MS what was maintained in all diagnostic criteria, which have been published up till now[1]. Current criteria were published in 2017 and enable diagnosing MS even in patients, who earlier could not have MS diagnosed. This results from the facts that CSF oligoclonal bands present in patients with DIS without DIT are enough to MS diagnose[2]. Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is a disease of small vessels related to gene NOTCH3 mutations leading to symptoms of migraine with aura, recurrent ischemic incidences, cognitive impairment and behavioral disturbance.

Abbrevations: MS: Multiple Sclerosis; DIT: Dissemination in Time; DIS: Dissemination in Space; CT: Computed Tomography; MRI: Magnetic Resonance Imaging; TPO: Thyroid Peroxidase Antibody; TG: Anti-Thyroglobulin Antibody; CADASIL: Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy; GOM: Granular Osmophilic Material

Abstract| Case Report| Discussion| References|