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Mini ReviewOpen Access

Neurobiological Mechanisms in Depression and Chronic Pain: A Mini Review

Volume 6 - Issue 2

Ana Carolina Costa da Roza1, Eduardo Tavares Lima Trajano*1, Ana Paula da Silva Ramos1, Beatriz Barbosa De Assis1, Fernando Lacerda1, Fernando Vieira De Abreu Bueno1, Marco Felipe Bouzada Marcos1, Marco Aurélio Dos Santos Silva1, Carlos Eduardo Cardoso1, Marco Orsini1-2, Victor Hugo Bastos2, Marcos RG De Freitas3, Acary Bulle Oliveira3 and Larissa Alexsandra Da Silva Neto Trajano1

  • Author Information Open or Close
    • 1Master Program in Applied Health Sciences, Severino Sombra University, Brazil
    • 2Department of Physiotherapy, Federal University of Piaui (Brain Mapping and Plasticity Laboratory), Brazil
    • 3Departamento de Neurologia, Federal University of Rio de Janeiro, Brazil

    *Corresponding author: Eduardo Tavares Lima Trajano, Pro-Rectory of Research and Graduate Studies, Professional Master’s Degree in Applied Science in Health, Severino Sombra University, Expedicação Oswaldo de Almeida Ramos Avenue, 280 Centro 27700-000 Vassouras RJ, Brazil

Received: June 26, 2018;   Published: July 03, 2018

DOI: 10.26717/BJSTR.2018.06.001330

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Depressive disorders affect approximately 322 million people around the world. People affected by chronic pain are more likely to develop depression. This occur because depression and chronic pain share some neurobiological mechanisms that may overlap. The objective of this study is to perform a review of the common neurobiological and pathophysiological factors between depression and chronic pain.

Keywords: Depression; Pain; Neurotransmitters

Abbrevations: IC: Insular Cortex; CCA: Anterior Cingulate Cortex; HPA: Hypothalamic-Pituitary-Adrenal Axis; CRH: Corticotropin Releasing Hormone; ACTH: Adrenocorticotropic Hormone

Abstract| Introduction| Discussion| Conclusion| References|