The Influence of NSAIDS on Osseointegration of Dental Implants A Systematic Review

Maryam Alhindi*, Hasan Muaddi, Mohammed Almosairy, Abdullah Alshebany and Malik Alabdulkader

Received: June 19, 2018;   Published: June 28, 2018

DOI: 10.26717/BJSTR.2018.06.001315

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Abstract

Objective:To determine whether there is enough data to support prescribing NSAID is likelyhas negative effect on osseointergration or not.

Materials and Methods:The Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) statement was used in this study. The clinical question in “PICO” format was: Do NSAIDs Inhibit the osseointegration of the dental implant? PubMed, MEDLINE, ScienceDirect and Cochrane Library was searched for articles published up until march 4, 2018.

Results: The search resulted in 371 articles. After selection according to the eligibility criteria, four studies fulfilled were included (Three RCT doubled blind and one retrospective cohort study) with a total of 217 patients analyzed, and 610 implants placed. Administration of a short course of systemic ibuprofen for post-operative pain management subsequent to implant placement may not have a significant effect on the marginal bone around dental implants in the early healing period.

Conclusion: The survival rate of implants in patients using NSAIDs in short term does not differ from the survival rate in healthy patients not using NSAIDs or using placebo. However, a greater number of prospective studies and clinical trials in the future is essential to support more solid conclusions.

Keywords: Dental Implants; Nonsteroidal Antiinflammatory Drugs; Cyclooxygenase 2 Inhibitor; Meloxicam; Osseointegration; Bone Healing

Abbreviations: PRISMA: Preferred Reporting Items for Systematic Reviews and Meta-Analysis; COX: Cyclo Oxygenase; DM: Diabetes Mellitus

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