Cellular Plasticity in Cutaneous Wound Healing

Tang XieLe Liu, ZhiLi Deng and Ji Li*

Received: June 07, 2018;   Published: June 20, 2018

DOI: 10.26717/BJSTR.2018.05.001255

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Abstract

TPlasticity refers to the capacity of cells to acquire an alternate fate in response to diverse influences. Wound healing is a dynamic and overlapped process including three phases - inflammation, proliferation, and tissue remodeling, involving soluble mediators, blood cells, extracellular matrix, and parenchymal cells. After injury, mature differentiated cells hold within potential to adopt a progenitor-like phenotype (Dedifferentiation) or convert into distinct lineages (Transdifferentiation). Besides, some stem/progenitor cell populations are able to switch into another type, mobilized to repair a wound (Transdetermination). This mini review aims to briefly discuss the phenomenon and mechanisms of the cellular plasticity in cutaneous wound healing for boosting regenerative medicine

Keywords: Cellular plasticity; Reprogramming; Dedifferentiation; Transdifferentiation; Wound Healing

Abbreviations: Th1: T helper 1 Lymphocytes; Th2: T helper 2 Lymphocytes; IFN-γ: Interferon-γ; MFG-E8: Milk Fat Globule Epidermal Growth Factor-8; SD: Sebaceous Duct; IFE: Interfollicular Epidermis; HF: Hair Follicle; SG: Sebaceous Gland; Gata6: Transcription Factor Gata-6; Lgr6: Leucine-Rich Repeat-Containing G-Protein Coupled Receptor 6; Lrig1: Leucine-Rich Repeats and Immunoglobulin-Like Domains Protein 1; Blimp1: PR Domain Zinc Finger Protein 1; ECM: Extracellular Matrix; MSC: Mesenchymal Stem Cells; I.V : Intravenous; GFP: Green Fluorescent Protein; TGF-β: Transforming Growth Factor β; Ang II: Angiotensin II; ET-1: Endothelin-1; P38-MAPK: p38 Mitogen-Activated Protein Kinases; SRF: Serum Response Factor ; TRPC6: Transient Receptor Potential Cation Channel, Subfamily C, Member 6; αSMA: Alpha Smooth Muscle Cell Actin; TβRII : Transforming Growth Factor Beta Receptor II; TβRI: Transforming Growth Factor Beta Receptor I; ALK5: Anaplasticlymphoma Kinase 5; Smad2/3/4: Mothers Against Decapentaplegic Homolog 2/3/4; SBEs: Bind Smad-Binding Elements; BMP: Bone Morphogenetic Protein

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