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*Corresponding author:Khalid Al Nedawi, Department of Nephrology, Canada
Received: June 12, 2018; Published: June 19, 2018
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Nuclear Receptors are a superfamily of transcription factors that exhibit multiplefunctions in health anddisease . These receptors play essential roles in various physiological processes; including metabolism, immunity, developmental patterning and cell proliferation  typically nuclear receptors are activated bysteroid hormones, suchas estrogens, androgens, progesterone, and various other lipid-soluble signals, includingretinoic acid, oxysterols, and thyroid hormone. The ligands can cross the plasmamembrane anddirectly interact with the receptors in the cytoplasm, causing theirtranslocation to the nucleus . Within the nucleus, the receptors bind DNA and activatespecific responsive genes.
Keywords: Metabolism; Immunity; Proliferation; Exogenous; Retinoic Acid; Translocation; Retinoic Acid; Cancer; Genome; Receptors
Abbrevations: AR: Androgen Receptor; ER: Estrogen Receptor; EGFR: Epidermal Growth Factor Receptor; CRPC: Castration Resistant Prostate Cancer; PSA: Prostate Specific Antigen